Chosen Solution

After replacing my iPhone 6s screen, everything seemed to be working fine. But occasionally the screen will become completely unresponsive. Typically the home, volume, and power buttons don’t work either. On occasion, they do. Performing a hard reboot temporarily fixes it. I imagine this is due to there being something up with the connectors. Maybe a pin or some dirt/glass from my old screen. Has anybody else experienced this or have a solution?

I haven’t seen this happen yet. You may want to open it up, and check everything out. You can test the old display, if it’s operational, to see if you’re still getting the same results. Make sure to hold down the power button, after you’ve disconnected the display and battery, to discharge the phone, before plugging anything else in. Let us know what you get after these findings, if there’s anything else we can do to help

You noted you couldnt test your old display. I’d test a different display. I know the home button and power button not working seems like an iOS issue, but I’ve seen displays cause over all delay or lag. If the iPhone didnt have the issue before, then I’d bet the display is the problem.